ICG PEG4-Alkyne

Catalog No. POG1616
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1 mg $200.00
5 mg $650.00
25 mg $2,400.00
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Description

ICG PEG4-Alkyne is a copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reagent of near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging. The alkyne reactive group is connected to ICG through a tetraethylene linker. NIR fluorescence allows to observe the deep image from the surface of skin and being utilized in a wide range of research fields. The maxima of Ex/Em values are at 785/812 nm. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical property. ICG PEG4-alkyne couples with an azide to form 1,4-disubstituted 1,2,3-triazole inside of living systems without interfering native biochemical processes. Prior to perform CuAAC, the azide functionality should be introduced onto counterpart biomolecule by means of chemical or genetic modification. We offer ICG PEG4-alkyne as a click chemistry reagent dye for cellular imaging and nucleotide functionalization. 

Specifications

Fluorophore: ICG

Reactive group: Alkyne

Excitation/Emission Max.(nm): 785/812

Extinction coefficient: ≥ 218,000 cm-1M-1

CF280: 0.05

Appearance: Green Solid

Molecular Weight: 944.23 g/mol

Solubility: DMF, DMSO

Storage conditions: -20 ℃, protect from light




Citation & Reference

1. Masashi Gotoh. Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. J Thorac Cardiovasc Surg 126.6 (2003): 1916-21.


2. Aaron M. Mohs. An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. IEEE Trans Biomed Eng 62.5 (2015): 1416-24.


3. Mohammed Hassan. Near Infrared Fluorescence Imaging with ICG in TECAB Surgery Using the da Vinci Si Surgical System in a Canine Model. J Card Surg 27.2 (2012): 158-162.


4. R. C. Benson. Fluorescence properties of indocyanine green as related to angiography. Phys Med Biol 23.1 (1978): 159-63.


5. Mitsuharu Miwa. The Principle of ICG Fluorescence Method. The Open Surgical Oncology Journal 2 (2010): 26-28.

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