qFlamma® Black01 Hydrazide

Catalog No. QWH1001
PACKING UNIT

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1 mg $121.00
5 mg $441.00
25 mg $882.00
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Description

qFlamma® Black01 Hydrazide is an aldehyde and ketone reactive universal dark quencher that the absorption range covers from 400 to 800 nm with no native fluorescence. Black01 quencher displays high absorption coefficient, superb stability and aqueous solubility. Hydrazides can label aldehyde and ketone through reductive amination reaction to form an imine linkage. The main labeling target for hydrazides are reducing sugars on biomolecules, and prior to conjugation, primary and secondary alcohols on polysaccharide and glycoprotein should be oxidized to corresponding aldehyde and ketone. We offer qFlamma® Black01 Hydrazide to label biomolecules bearing aldehyde or ketone for designing probes consisting of spectrally paired fluorophore and quencher.

Specifications

Functionality: Dark quencher

Reactive group: hydrazide

Absorption max. (nm): 490

Absorption range (nm): 400 ~ 800

Appearance: green solid

Molecular Weight: 735.79 g/mol 

Solubility: Water, DMF, DMSO

Storage conditions: -20 ℃, protect from light

 

Citation & Reference

1. Arnaud Chevalier. Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chemistry 19.5 (2013): 1686-99.

 

2. Arnaud Chevalier. Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes. Org. Lett 2013 15.23 (2013): 6082–6085.

 

3. Arnaud Chevalier. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Letters 55.50 (2014): 6759-6763.

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