qFlamma® Black01 Alkyne

Catalog No. QWK1001
PACKING UNIT

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1 mg $176.00
5 mg $552.00
25 mg $1,103.00
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Description

qFlamma® Black01 Alkyne is a copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reagent of universal dark quencher. Black01 quencher displays high absorption coefficient, superb stability and aqueous solubility, and the absorption range covers from 400 to 800 nm with no native fluorescence. Black01 Alkyne couples with an azide to form 1,4-disubstituted 1,2,3-triazole, and prior to perform CuAAC, an azide should be introduced to the probe or counterpart biomolecule by means of chemical or genetic modification. We offer qFlamma® Black01 Alkyne as a click chemistry reagent in designing probes consisting of spectrally paired fluorophore and quencher for multiplexed bio-analysis and nucleic acid hybridization.

Specifications

Functionality: Dark quencher

Reactive group: alkyne

Absorption max. (nm): 490

Absorption range (nm): 400 ~ 800

Appearance: green solid

Molecular Weight: 758.82 g/mol  

Solubility: water, DMF, DMSO

Storage conditions: -20 , protect from light 

Citation & Reference

1. Arnaud Chevalier. Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chemistry 19.5 (2013): 1686-99.

 

2. Arnaud Chevalier. Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes. Org. Lett 2013 15.23 (2013): 6082–6085.

 

3. Arnaud Chevalier. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Letters 55.50 (2014): 6759-6763.

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